Peter J. Cullen

The paper identifies neuronal and astrocytic membrane proteins dependent on Retromer for endosomal recycling, highlighting SNX27-Retromer's role in glutamate transporter trafficking.

This study identifies the RAB32-LRMDA-Commander complex and shows its role in melanosome biogenesis and pigmentation, revealing the mechanism of oculocutaneous albinism type 7.

The paper identifies Retromer as a hub for RAB GTPase regulation through proximity proteomics and biochemical analysis.

The paper identifies a new VPS29 isoform, VPS29C, which exhibits auto-inhibition limiting its association with Retriever and Retromer accessory proteins, revealing new complexity in Retromer function.

The paper identifies the mechanism by which SNX17 cargo is selected for entry into the Commander recycling pathway through direct binding to the Retriever sub-complex.

This study identifies RSS as a recyclinopathy caused by dysfunction in the Commander endosomal recycling pathway, linking it to multiple tissue malformations.

The paper uses a multiomic approach to study Retromer's role in lysosomal health in human neuroglioma cells, revealing proteomic and transcriptomic changes linked to neurodegeneration.

This study identifies LRFN2 as a new SNX27-dependent cargo that regulates AMPA receptor trafficking and synaptic function, revealing an indirect mechanism for SNX27's role in neurological conditions.