Author

Martina Parente

Roma Tre UniversityORCID 0000-0002-9135-567XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Amélie BarthelemyiD· 3 shared Frank W. PfriegeriD· 3 shared Valentina PallottiniiD· 3 shared Claudia ToniniiD· 2 shared Sara CaputoiD· 2 shared Alessandra SacchiiD· 1 shared Chiara MarioliiD· 1 shared Christian Galmiche· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Amélie BarthelemyORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 3, 2026

Pharmacological BET Protein Inhibition Reverts Niemann-Pick Type C Disease-Associated Changes in Human iPSC-Derived Cortical Neurons

Federica Benigni, Martina Parente, Chiara Marioli…·Claudia Compagnucci

This study uses iPSC-derived neurons from NPC1 patients to show that BET inhibition with JQ1 improves neuronal viability and reduces cholesterol accumulation.

DOI 10.64898/2026.08.31.747771

humanexperimental assay

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NeurosciencebioRxivPreprintJun 29, 2026

Effects of bromodomain protein inhibition in a mouse model of Niemann-Pick type C disease

Martina Parente, Amélie Barthelemy, Sara Caputo…·Valentina Pallottini

This study investigates the effects of bromodomain protein inhibition in a mouse model of Niemann-Pick type C disease, finding sex-dependent therapeutic benefits in male mice.

DOI 10.64898/2026.06.24.734200

mousebulk RNA-seq

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Cell BiologyInternational Journal of Molecular SciencesPeer-reviewedJun 16, 2025

Bromodomain proteins as new drug target for an inborn lysosomal defect

Martina Parente, Amélie Barthelemy, Claudia Tonini…·Valentina Pallottini

This study investigates bromodomain proteins as a therapeutic target for Niemann-Pick type C disease, showing that JQ1 improves NPC1 levels and reduces cholesterol accumulation in patient-derived fibroblasts.

3 citations

humanbulk RNA-seq

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