Shimon Marom

The paper introduces a bounded multiplicative framework to explain axonal conduction slowdown, showing it accounts for the stability of the slowdown distribution across lengths.

The paper quantifies conduction velocity changes along axonal branches and finds a right-skewed distribution of velocity ratios that is invariant across branch lengths and neuron positions.

The paper shows axons maintain high spike transmission fidelity under spontaneous activity but can fail under sustained 10 Hz stimulation, with simulations attributing this to sodium channel inactivation.

This study shows that slow inactivation of Na+ channels normalizes axonal firing reliability when channel distributions are uneven.

The paper experimentally validates the Hodgkin-Huxley phase diagram using dynamic clamp and Kv1.3 channels in Xenopus oocytes, revealing activity-dependent and hysteretic dynamics.