Hongguang Ren

This paper introduces a one-pot CRISPR-Cas12a diagnostic strategy using base-mismatched crRNA, enabling rapid and specific detection of pathogens without PAM re-design or costly modifications.

SemVac uses LLMs to predict vaccine antigens by analyzing literature-derived protein descriptions, outperforming existing methods and identifying new candidates with experimental validation.

This paper develops AENCS to engineer antibodies targeting glycosylated epitopes, demonstrating ACC01's 24-fold improved neutralization against SARS-CoV-2 variants.

The paper proposes a 3-step framework for bacterial taxonomy analysis based on protein domains and selects the best model candidates to improve classification accuracy and biological interpretation.

This study maps the in vivo RNA-RNA interactome of SARS-CoV-2 during its life cycle, revealing structural features and dynamics that regulate replication, transcription, and frameshifting.

The paper proposes a 3-step framework for bacterial taxonomy analysis based on protein domains, selects the best model candidates, and provides taxonomy suggestions for NCBI.