Gain-of-function mutation in SKAP2 leads to type 1 diabetes and broader autoimmunity through hyperactive integrin signaling in myeloid cells
Courtney M. Tamaki, Chester E. Chamberlain, Clare L. Abram…·Clifford A. Lowell
Author
National Jewish HealthORCID 0000-0002-9191-9893Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Courtney M. Tamaki, Chester E. Chamberlain, Clare L. Abram…·Clifford A. Lowell
Marika Orlov, Mallory Karr, Naoko Hara…·Christopher M. Evans
This study shows that amoxicillin causes long-term gut dysbiosis and reduces type-17 immune tone in the lungs.
Liyen Loh, David J. Orlicky, Andrea Spengler…·Laurent Gapin
This study investigates the role of MAIT cells in a genetically diverse mouse model of spontaneous colitis, finding that MAIT cells drive chronic inflammation and colonic pathology.
Emma Louise Robinson, Rushita Adhikari Bagchi, Jennifer L. Major…·Timothy A. McKinsey
This study shows that inhibiting HDAC11 in adipocytes increases UCP1 expression and thermogenesis, even when beta-AR signaling is blocked.
Katherine A. Waugh, Ross Minter, Jessica A Baxter…·Joaquin Maximiliano Espinosa
The paper shows that correcting interferon receptor gene dosage in a mouse model of trisomy 21 rescues multiple key phenotypes associated with Down syndrome.