Author

Hongli Zhou

Vazyme BiotechORCID 0000-0002-9198-6228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Assay:multiome· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Guiying Ji· 2 shared Qiuheng JiniD· 2 shared Wei HeiD· 2 shared Xiaoyu Xu· 2 shared Kunkun ZhangiD· 1 shared Minghao XuiD· 1 shared Ya Dai· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

Guiying Ji

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintNov 12, 2026

Engineering the thumb loop of T7 RNA polymerase improves the integrity of long RNA transcripts

Wei He, Hongli Zhou, Guiying Ji…·Qiuheng Jin

This study engineers the thumb loop of T7 RNA polymerase to enhance the integrity of long RNA transcripts, identifying specific substitutions that improve stability across different transcript lengths.

DOI 10.64898/2026.11.10.765520

long-read sequencingmultiome

𝕏 PostBluesky

BioengineeringbioRxivPreprintJul 29, 2026

Maximizing the productivity of co-transcriptional in vitro transcription

Wei He, Kunkun Zhang, Guiying Ji…·Qiuheng Jin

This study optimizes co-transcriptional in vitro transcription (co-IVT) to achieve high mRNA yield and quality, reducing impurities and improving production efficiency for therapeutic applications.

DOI 10.64898/2026.07.28.740954

experimental assaydrug response / drug discovery

𝕏 PostBluesky