Andrew D. Hecht

This study examines how different inhibitors affect enzyme specificity, finding that noncompetitive and mixed inhibitors can alter specificity, while competitive and uncompetitive inhibitors do not.

The paper develops a kinetic model of CRISPR-Cas9 substrate selection and cleavage, showing specificity improvements arise from kinetic changes, not binding affinity.

The paper shows that E. coli exhibits overlapping stress responses to starvation and lactose toxicity, with distinct gene expression shifts and functional signatures in each condition.