Integrative transcriptomics and electrophysiological profiling of hiPSC-derived neurons identifies novel druggable pathways in Koolen-de Vries Syndrome
Anouk H. A. Verboven, Sofía Puvogel, Brooke L. Latour…·Nael Nadif Kasri
Author
Radboud University Medical CenterORCID 0000-0002-9252-6020Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Anouk H. A. Verboven, Sofía Puvogel, Brooke L. Latour…·Nael Nadif Kasri
Marc P. M. Soutar, Daniela Melandri, Benjamin J. O’Callaghan…·Hélène Plun‐Favreau
The paper identifies KAT8 and KANSL1 as regulators of PINK1-mitophagy linked to Parkinson's disease risk, suggesting a novel pathway for therapeutic targeting.
Teun M. Klein Gunnewiek, Anouk H. A. Verboven, Iris Pelgrim…·Nael Nadif Kasri
Britt Mossink, Anouk H. A. Verboven, Eline van Hugte…·Monica Frega
The paper benchmarks MEA recordings from healthy hiPSC-derived neuronal networks to establish standards for experimental design and analysis, showing MEAs are robust for disease-phenotyping and drug discovery.
Katrin Linda, Elly Lewerissa, Anouk H. A. Verboven…·Nael Nadif Kasri
This study shows that KANSL1 deficiency leads to oxidative stress-induced autophagy, causing synaptic dysfunction and neuronal network impairments in neurons.
Britt Mossink, Jon-Ruben van Rhijn, Shan Wang…·Nael Nadif Kasri
This study investigates the role of CDH13 in regulating GABAergic inhibition in human-derived neuronal networks and shows its impact on E/I balance.