Yves V. Brun

This paper analyzes the evolution and functional diversification of the WhiG sigma factor in Actinomycetota, revealing two distinct clades with different regulatory mechanisms and expanded biological roles.

This study uses cryo-ET and subtomogram averaging to determine the in situ architecture of the Tad pilus machine in Caulobacter crescentus, revealing its assembly intermediates and structural framework.

The paper shows how the Tad motor ATPase CpaF achieves reversible pilus motion through physical inversion of its orientation, using a single unidirectional catalytic cycle.

This study identifies CpaL as a mechanosensory protein involved in pilus-mediated surface sensing in Caulobacter crescentus, showing that its deletion increases surface adhesion through enhanced holdfast production.

This study investigates the functional roles of BacA subdomains in stalk morphogenesis in A. biprosthecum, showing that polymerization, membrane association, and interactions with SpmX are essential for proper stalk formation.

The paper reveals diverse cell elongation mechanisms in closely related bacterial species using fluorescent D-amino acids and shows phenotypic plasticity in elongation complexes.

The paper determines cryo-EM structures of CpaF in different conformations and proposes a rotary mechanism of catalysis for Tad pilus assembly and disassembly.

This paper identifies a specialized operon in Vibrio cholerae that senses antimicrobial peptides and activates multiple resistance systems, including efflux pumps and outer membrane modifications.

This study examines broad-host-range Vibrio phages, identifying genetic features and ecological trade-offs that influence their host range and environmental distribution.

This study identifies a phosphorelay pathway, HmrABCX, that regulates the transition from motile to sessile lifestyle in Caulobacter crescentus independently of HfiA, and shows its role in environmental stress responses.