Author

Samantha Y. Tse

University of Massachusetts Chan Medical SchoolORCID 0000-0002-9493-4538Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 1

Frequent Co-Authors

Read Pukkila-WorleyiD· 2 shared Amanda Page· 1 shared Fiachra HumphriesiD· 1 shared Khursheed Alam WaniiD· 1 shared Nicholas PetersoniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

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5 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

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2 papers

Recent·Most cited

ImmunologyImmunityPeer-reviewedSep 18, 2024

Activation of intestinal immunity by pathogen effector-triggered aggregation of lysosomal TIR-1/SARM1

Samantha Y. Tse, Khursheed Alam Wani, Nicholas Peterson…·Read Pukkila-Worley

The paper identifies lysosomal TIR-1/SARM1 as a sensor for oxidative stress induced by pathogenic bacteria, activating intestinal immunity in C. elegans.

19 citations

C. elegansproteomics

𝕏 PostBluesky

ImmunologyCell ReportsPeer-reviewedSep 1, 2024

Lysosomal integrity suppresses TIR-1/SARM1 aggregation to restrain toxic propagation of p38 innate immunity

Samantha Y. Tse, Read Pukkila-Worley

The paper identifies lysosomal integrity as a regulator of TIR-1/SARM1 aggregation, preventing toxic p38 immune activation in C. elegans.

9 citations

C. elegansexperimental assay

𝕏 PostBluesky