Author

John Osei Sekyere

University of PretoriaORCID 0000-0002-9508-984XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Microbiology· 2 Genomics· 1 Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Masego MmatliiD· 3 shared Nontombi Marylucy MbelleiD· 3 shared Eli MordechaiiD· 2 shared Jason P. TramaiD· 2 shared Martin E. Adelson· 2 shared Anel BoschiD· 1 shared Ayodeji B. OyenihiiD· 1 shared Charulata Trikannad· 1 shared

Activity by Year

2023-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Masego MmatliORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

PathologybioRxivPreprintDec 30, 2024

Molecular and Pathological Characterization of Cervicovaginal Specimens Evince Significant Protection Against HPV Infections, Bacterial Vaginosis, and Epithelial Cell Abnormalities by Lactobacillus species

John Osei Sekyere, Jason P. Trama, Martin E. Adelson…·Eli Mordechai

The paper analyzes cervicovaginal specimens to show that Lactobacillus species, particularly L. crispatus, protect against HPV infections, bacterial vaginosis, and epithelial abnormalities.

DOI 10.1101/2024.12.30.630800

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintAug 27, 2024

Plasmid-borne mcr-1 and Replicative Transposition of Episomal and Chromosomal blaNDM-1, blaOXA-69, and blaOXA-23 Carbapenemases in a Clinical Acinetobacter baumannii Isolate

Masego Mmatli, Nontombi Marylucy Mbelle, John Osei Sekyere

The paper characterizes the genetic resistance mechanisms in a multidrug-resistant Acinetobacter baumannii isolate, identifying plasmid-borne mcr-1 and chromosomal carbapenemase genes linked to replicative transposition and genomic plasticity.

1 citation

humanwhole-genome sequencing

𝕏 PostBluesky

MicrobiologyFrontiers in Cellular and Infection MicrobiologyPeer-reviewedJun 28, 2024

Molecular Characterization of Vaginal Microbiota Using a New 22-Species qRT-PCR Test to Achieve a Relative-abundance and Species-based Diagnosis of Bacterial Vaginosis

Ayodeji B. Oyenihi, Ronald Haines, Jason P. Trama…·John Osei Sekyere

This paper develops a qRT-PCR test targeting 22 BV-associated species and uses it to create a diagnostic index that classifies vaginal microbiome states into BV-positive, BV-negative, or transitional BV.

11 citations

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologyFrontiers in Cellular and Infection MicrobiologyPeer-reviewedFeb 28, 2024

Molecular Epidemiology of multidrug-resistant Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli outbreak among neonates in Tembisa Hospital, South Africa

John Osei Sekyere, Masego Mmatli, Anel Bosch…·Mohamed Said

The paper investigates an outbreak of multidrug-resistant bacteria in a neonatal ward, identifying clonal and plasmid-mediated spread of resistance genes.

15 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

Molecular BiologybioRxivPreprintDec 15, 2023

Genomic, Epigenomic, and Transcriptional Characterisation of Carbapenem and Colistin Resistance Mechanisms in Klebsiella pneumoniae and Enterobacter species.

Masego Mmatli, Nontombi Marylucy Mbelle, Petrus Bernard Fourie, John Osei Sekyere

This study characterizes genomic, epigenomic, and transcriptional resistance mechanisms in carbapenem and colistin-resistant Klebsiella pneumoniae and Enterobacter isolates.

DOI 10.1101/2023.12.15.571804

bacteria (other)whole-genome sequencing

𝕏 PostBluesky