Shuxiang Li

This study uses molecular dynamics and cryo-ET to show histone tails drive chromatin compaction through specific interactions, revealing their role in both structural organization and nucleosome communication.

The paper assesses the oncogenic potential of histone missense mutations using whole-exome sequencing data from over 12,000 cancer patients, finding that these mutations affect DNA repair interactions and increase mutagenesis.

This study shows survivin interacts with BAF/SWI complex at bivalent chromatin regions to repress DNA repair in IFNγ-stimulated CD4+ T cells, promoting autoimmune profiles.

The paper introduces NuPose, a deep residual network for predicting nucleosome positions and associated features across the genome with high accuracy.

The paper shows survivin interacts with PRC2, preventing H3K27 methylation and gene silencing in CD4+T cells.