Author

Nico Appold

Friedrich-Alexander-Universität Erlangen-NürnbergORCID 0000-0002-9564-484XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Jona KayseriD· 2 shared Timon CitakiD· 2 shared Auguste PalmiD· 1 shared Elias Fischer· 1 shared Maximilian Eiche· 1 shared Serhii AifiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

Jona KayserORCID

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2 papers

Recent·Most cited

Biophysicsnpj Artificial IntelligencePeer-reviewedOct 8, 2026

Reinforcement Failing guides the discovery of emergent spatial dynamics in adaptive tumor therapy

Serhii Aif, Maximilian Eiche, Nico Appold…·Jona Kayser

This paper introduces Reinforcement Failing, an AI framework that identifies emergent spatial dynamics in adaptive tumor therapy by refining training environments.

1 citation

deep learningstatistical model

𝕏 PostBluesky

BiophysicsbioRxivPreprintFeb 26, 2026

Spatial resource dynamics control resistance escape

Nico Appold, Timon Citak, Auguste Palm, Jona Kayser

This study shows how intermittent treatment pulses reshape resource landscapes and spatial growth zones, enabling resistant mutants to escape confinement and drive therapy failure.

DOI 10.64898/2025.12.22.695823

yeastexperimental assay

𝕏 PostBluesky