Author

Karl M Gogan

Trinity College DublinORCID 0000-0002-9570-8671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Joseph KeaneiD· 2 shared Aenea AI BrugmaniD· 1 shared Anjali S YennemadiiD· 1 shared Cilian Ó MaoldomhnaighiD· 1 shared Dearbhla M MurphyiD· 1 shared Donal J CoxiD· 1 shared Emily DuffiniD· 1 shared Finbarr O’ConnelliD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

Joseph KeaneORCID

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2 papers

Recent·Most cited

ImmunologyEuropean Journal of ImmunologyPeer-reviewedJul 11, 2024

Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human monocyte-derived macrophages and blunt glycolysis in response to antigenic stimuli.

Gina R. Leisching, Anjali S Yennemadi, Karl M Gogan, Joseph Keane

This study examines how chronic exposure to type I interferons affects macrophage metabolism, revealing distinct metabolic profiles and functional changes in response to antigenic stimuli.

5 citations

humanbulk RNA-seq

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ImmunologyeLifePeer-reviewedJun 20, 2024

Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis dependent functional plasticity.

Donal J Cox, Sarah A Connolly, Cilian Ó Maoldomhnaigh…·Joseph Keane

This study shows that human airway macrophages reprogram their metabolism in response to IFN-γ, leading to glycolysis-dependent functional plasticity that differs from monocyte-derived macrophages.

29 citationstop 4%

humanproteomics

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