Daniel Backenroth

SHaploseek is a sequencing-only method for comprehensive preimplantation genetic testing that achieves high concordance with existing methods and improves sensitivity in subtelomeric regions.

The paper analyzes genome-wide data from medieval German Jews to show the Ashkenazi founder event occurred before the 14th century, with genetic heterogeneity not present in modern Ashkenazi Jews.

This paper predicts the utility of polygenic embryo screening for disease based on selection strategies and finds that selecting the lowest PRS embryo can significantly reduce disease risk.

The paper develops statistical tests to detect deviations from Hardy-Weinberg equilibrium on the X chromosome in sex-biased admixed populations, showing improved performance over existing methods.

FUN-LDA predicts tissue-specific functional effects of noncoding variants by integrating epigenetic data, showing higher accuracy than existing methods in eQTL and GWAS analyses.