Nikki J. Marks

This paper investigates the role of serotonin signaling in juvenile Fasciola hepatica, showing it modulates motility and growth through specific receptor mechanisms.

This study identifies Wnt/β-catenin signaling as critical for juvenile Fasciola hepatica growth and development, with pharmacological inhibition showing potential for novel therapeutic strategies.

This paper identifies and characterizes neoblast-like stem cells in Fasciola hepatica, showing their self-renewal, differentiation, and radiation sensitivity, and identifies potential drug targets.

This paper expands the Fasciola hepatica miRNome by identifying 61 new miRNAs and provides the first developmental expression profiles and functional annotations of miRNAs in this parasite.

This study compares transcriptomic profiles of in vitro and in vivo maintained Fasciola hepatica juveniles to identify gene expression differences that may explain growth and development variations.

The paper identifies conserved neuropeptides and their encoding genes in parasitic nematodes and characterizes their physiological activity on reproductive musculature.

This study investigates RNAi dynamics in developing juvenile Fasciola hepatica, finding reduced RNAi efficacy in early stages and improved efficiency with repeated dsRNA exposure.

The paper identifies extrasynaptic volume transmission as a non-synaptic signaling route in nematodes, showing that neuropeptides in pseudocoelomic fluid modulate reproductive function and behavior.

This paper identifies 146 GPCRs in Fasciola hepatica, including 18 unique rhodopsins, and provides ligand-receptor predictions, offering potential targets for new anthelmintic drugs.