Michael J. Hendzel

This study identifies chromatin reorganization and histone mark changes in HGPS VSMCs, linking them to vascular pathology through disrupted enhancer-promoter interactions.

This study identifies RNA interaction at the NID/RBD of MeCP2 and shows it inhibits MeCP2-NCoR binding, suggesting a role in Rett syndrome pathophysiology.

The paper identifies HDAC2 as the main regulator of H4K16ac in HGPS VSMCs and shows that its inhibition restores acetylation and delays senescence.

The paper investigates charge-dependent phase separation in chromatin using electron spectroscopic imaging and shows that chromatin organization changes with histone modifications and environmental factors.