Author

Sita S. Chandrasekaran

University of California, San FranciscoORCID 0000-0002-9604-861XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:multiome· 1

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April PawlukiD· 1 shared Cyrus TauiD· 1 shared Matthew NemethiD· 1 shared Patrick D. HsuiD· 1 shared Silvana KonermanniD· 1 shared

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1 shared paperMolecular Biology

April PawlukORCID

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintJan 29, 2024

Rewriting endogenous human transcripts with trans-splicing

Sita S. Chandrasekaran, Cyrus Tau, Matthew Nemeth…·Patrick D. Hsu

This paper introduces RESPLICE, a CRISPR-based trans-splicing system that efficiently edits endogenous human transcripts, achieving up to 90% trans-splicing efficiency in sorted cells.

5 citations

humanmultiome

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