Jesús María Hernández‐Rivas

This study shows MDS hematopoietic stem cells reprogram their differentiation state to bypass venetoclax sensitivity through genetic mutations and transcriptional changes.

The paper identifies a high-risk subgroup in myelodysplastic syndromes with isolated trisomy 8 using mutational profiles.

This study shows that targeting splice donor sites with sgRNAs improves CRISPR/Cas9 knockout efficiency by increasing frameshift mutations and disrupting pre-mRNA splicing.