Author

Miguel de Jesus

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-9706-7249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Morgan HuseiD· 2 shared Alexander H. SettleiD· 1 shared Benjamin Y. WineriD· 1 shared Daan VorseleniD· 1 shared Eric Chan· 1 shared Hui LiuiD· 1 shared Jahan A. RahmaniD· 1 shared Justin R. CrossiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Morgan HuseORCID

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2 papers

Recent·Most cited

ImmunologyImmunityPeer-reviewedJul 13, 2026

MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion

Tanya Mitra, Jahan A. Rahman, Madeline A. Hwee…·Santosha Adipudi Vardhana

This study shows that MEK inhibition reduces mitochondrial dysfunction and terminal CD8+ T cell exhaustion by decreasing nutrient uptake and RNA polymerase II activity.

1 citation

humanproteomics

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Cell BiologyNature CommunicationsPeer-reviewedSep 18, 2024

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

Alexander H. Settle, Benjamin Y. Winer, Miguel de Jesus…·Morgan Huse

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

43 citationstop 2%

proteomicsexperimental assay

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