Philina Santarelli

This study shows that chronic Mycobacterium abscessus infection causes macrophage senescence, leading to pro-inflammatory cytokine secretion and secondary senescence in neighboring cells.

This study shows Sorafenib causes muscle wasting by disrupting chromatin regulators, leading to transcriptional changes and impaired muscle function.

The paper develops 4f-SAMMY-seq to map euchromatin and heterochromatin based on accessibility and solubility, and reconstructs their 3D compartmentalization in one experiment.