Molecular BiologyCell MetabolismPeer-reviewed
Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
Anne Hahn, Grace Ching Ching Hung, Arnaud Ahier…·Steven Zuryn
This study shows that misregulation of mitochondrial 6mA in C. elegans reduces mtDNA copy number, impairs OXPHOS, increases oxidative stress, and shortens lifespan.
26 citations