Molecular BiologyNature CommunicationsPeer-reviewed
Sequence-independent substrate selection by the eukaryotic wobble base deaminase ADAT2/3 involves multiple protein domains and distortion of the tRNA anticodon loop
Luciano G. Dolce, Aubree A. Zimmer, Laura Tengo…·Eva Kowalinski
This study presents the first structure of a eukaryotic ADAT2/3 deaminase bound to tRNA, revealing sequence-independent substrate selection and a novel gating mechanism for substrate entry.
27 citations