James Chuang

This study shows that cooperative self-assembly of transcriptional regulators can improve regulatory specificity and long-term stability of synthetic gene circuits in yeast.

The paper identifies suppressor mutations in yeast that allow survival without the essential transcription factor Spn1/Iws1 by revealing multiple pathways that compensate for its loss.

This study identifies a network of histone chaperones and elongation factors that coordinate transcriptional accuracy and chromatin structure through their physical interactions.

This study shows that Spn1 is essential for normal mRNA levels, splicing of ribosomal protein transcripts, and histone modifications in yeast.

This study shows Spt6 represses transcription initiation at thousands of intragenic promoters and regulates initiation at most genic promoters, proposing a model of initiation-site competition.