Molecular BiologyNature Structural & Molecular BiologyPeer-reviewed
Substrate-induced clustering activates Trim-Away of pathogens and proteins
Jingwei Zeng, Ana Filipa Santos, Aamir S. Mukadam…·Leo C. James
This study reveals how substrate-induced clustering activates TRIM21's ubiquitination activity for antiviral responses and protein degradation, introducing optogenetically controllable TRIM21-nanobody chimeras.
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