An Zhu

OpenAc4C compiles and analyzes ac4C epitranscriptome data from 33 species, identifying 536,745 ac4C sites and 4,766 pathogenic variants, and provides a web-based platform for exploration.

This study identifies 13 novel genetic associations and confirms 17 existing ones between SNPs and neonatal metabolites using genome-wide association analysis of maternal low-pass genomes.

This study identifies betaine metabolism as a key factor in aging in C. elegans and shows that senolytics extend lifespan by increasing betaine levels and enhancing autophagy and antioxidant capacity.