Alexander Thiemicke

The paper shows that stimulation rate, along with concentration, determines MAPK signaling and cell survival in budding yeast through a rate threshold mechanism.

The paper shows that gradual hyperosmotic stress allows human cells to survive by preventing caspase activation and accumulating proline, unlike acute stress.

The paper introduces CellDissect, a method for automated cell and nuclear segmentation in suspension cells using widefield images, and evaluates its accuracy against manual segmentation.

The paper develops experimental methodologies to control temporal changes in extracellular stimuli for studying dynamic cellular processes in single cells.