Meni Wanunu

NanoCortex provides a unified agentic framework for nanopore sequencing analysis, improving usability over general-purpose models by integrating data processing and biological interpretation.

The paper identifies rare bioactive tau oligomers in Alzheimer's brain that can induce templated misfolding and fibril formation, distinguishing them from non-bioactive oligomers.

The paper introduces a quality control method for synthetic RNA using Oxford Nanopore sequencing to assess integrity, sequence accuracy, and modification sites, improving synthesis fidelity and yield.

The paper compares pseudouridine modification sites in primary and immortalized human T cells using direct RNA sequencing, finding most sites are conserved with some cell-type specific differences.

The paper shows that N1-methylation at position 9 of mt-Leu(UAA) stabilizes wild-type mt-tRNA but destabilizes pathogenic variants, suggesting methylation control could be therapeutic.

This paper develops machine learning models to quantitatively measure pseudouridine occupancy in human mRNAs using synthetic controls, revealing site-specific requirements for accurate classification.

This study demonstrates a method to generate electro-osmotic flow using sticky ions, showing it works in both biological and solid-state nanopores.

The paper maps pseudouridylation sites in human cell lines using nanopore sequencing and shows how psi modifications affect translation through distinct mechanisms.

This study uses direct RNA sequencing to examine pseudouridylation dynamics in neurons under healthy and unhealthy conditions, finding changes in psi writer expression and site occupancy.

The paper develops a semi-quantitative method to detect pseudouridine modifications in human mRNAs using long-read nanopore sequencing and validates it with synthetic RNA controls.

The paper develops a DNA-enhanced CuAAC ligand for intracellular biomolecule labeling in live cells, demonstrating reduced copper toxicity and effective labeling.