Katharine L. Diehl

This study identifies Sirtuin 6 as a histone delactylase and shows its delactylase activity at H3K9 and H3K18, with additive effects to Class I HDACs in regulating histone Kla.

This study identifies that SIRT6 mono-ADP-ribosylates proteins with polyhistidine repeats when bound to dsDNA ends, revealing it as a histidine mARyltransferase.

This paper develops a genetically-encoded fluorescent biosensor to measure acetyl-CoA in live cells, showing its utility in E. coli and HeLa cells for detecting acetyl-CoA dynamics and compartmentalization.