Zhiguang Jia

The paper uses atomistic simulations to study voltage activation of BK channels, revealing unique VSD movement and coupling mechanisms distinct from canonical Kv channels.

This paper investigates how the small molecule NS11021 activates BK channels by increasing inner pore hydration through atomistic simulations.

The paper develops a predictive model for BK channel voltage gating using physics-based features and random forest, achieving accurate predictions with limited mutational data.