Author

Megan E. McLaughlin

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-9971-0111Unclaimed ORCID profile · follow to get notified of new preprints

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Systems Biology· 1

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

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Eiru KimiD· 1 shared Merve DedeiD· 1 shared Traver HartiD· 1 shared

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2020-2020 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperSystems Biology

Eiru KimORCID

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1 paper

Recent·Most cited

Systems BiologyGenome biologyPeer-reviewedOct 15, 2020

Multiplex enCas12a screens show functional buffering by paralogs is systematically absent from genome-wide CRISPR/Cas9 knockout screens

Merve Dede, Megan E. McLaughlin, Eiru Kim, Traver Hart

The paper shows that paralog buffering limits detection of synthetic lethal interactions in CRISPR screens, revealing many under-detected genetic dependencies.

105 citationstop 3%

humanCRISPR screen

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