Michael O. Breckwoldt

The paper identifies CD4+ tissue-resident memory T-cells as markers of response to immune checkpoint inhibition in high-grade glioma.

The paper shows that irradiation reprograms tumor endothelium to enhance T cell infiltration and effector function in gliomas, improving immunotherapy outcomes.

The paper shows brain metastases form gap-junction-coupled networks with coordinated calcium activity that drives proliferation and is inhibited by gap junction blockers.

BRIDGE correlates MRI with cellular data to predict brain disease states using deep learning and high-resolution microscopy.

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

The paper shows neurons form direct excitatory synapses with brain-metastatic breast and melanoma cancer cells, supporting metastasis and offering new therapeutic targets.

This paper introduces an AI-based pipeline for analyzing cerebral organoids using MRI, achieving high segmentation accuracy and quality classification.

The paper shows that TCA cycle dysfunction contributes to axonal energy deficiency in neuroinflammatory lesions and that restoring TCA enzymes can alleviate this deficit.