Peter‐Martin Bruch

This study identifies spatially distinct fibroblast subpopulations and niches in human myocardial fibrosis across different disease states and their associations with fibrotic remodeling and cardiac dysfunction.

This paper introduces a dual-photoreactive adapter to enable rapid, one-step DNA barcoding of antibody panels for multiplexed imaging.

The paper introduces spatialproteomics, a Python toolbox for analyzing highly multiplexed fluorescence images, demonstrating its use on lymph node and lymphoma data.

This study uses blood vessel organoids to model systemic sclerosis vasculopathy and fibrosis, showing that SSc serum induces epigenetic and molecular changes linked to endothelial dysfunction and potential therapeutic targets.

This study reveals that cellular differentiation drives intratumor heterogeneity in B-cell lymphomas, with distinct maturation states associated with different survival outcomes.

This paper introduces scNOVA, a method to analyze somatic structural variants in single-cell multiomics data, revealing their functional impacts on gene regulation and cancer pathways.

diffTF quantifies differential transcription factor activity and classifies TFs as activators or repressors using multi-omics data, identifying known and novel TFs in two case studies.