Author

Bikesh Kumar Nirala

Emory UniversityORCID 0000-0003-0082-1696Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Jason Todd YusteiniD· 2 shared Lyazat KurenbekovaiD· 2 shared Abhinaya MuruganandhamiD· 1 shared Irtisha SinghiD· 1 shared Juan DouiD· 1 shared Nino Carlo RainussoiD· 1 shared Ryan Lane Shuck· 1 shared Sarah S. Kappa· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Jason Todd YusteinORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 26, 2026

MYC-Hyperactivated Osteosarcoma Models Exhibit Resistance to Cabozantinib plus TIGIT Blockade

Sarah S. Kappa, Tajhal Patel, Bikesh Kumar Nirala…·Jason Todd Yustein

This study evaluates the efficacy of cabozantinib plus TIGIT blockade in osteosarcoma models, finding improved outcomes in p53-driven tumors but resistance in MYC-hyperactivated models due to myeloid recruitment and ECM remodeling.

DOI 10.64898/2026.09.21.753033

mousebulk RNA-seq

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Cancer BiologyMolecular Cancer ResearchPeer-reviewedJun 6, 2024

Intrinsic epigenetic state of primary osteosarcoma drives metastasis

Irtisha Singh, Nino Carlo Rainusso, Lyazat Kurenbekova…·Jason Todd Yustein

This study identifies chromatin activity differences in primary osteosarcoma tumors that correlate with metastatic potential and identifies genes involved in metastasis.

10 citations

humanChIP-seq

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