Brian T. Analikwu

This study examines how intercalating dyes affect DNA loop extrusion by SMC proteins, finding they alter extrusion rates and SMC activity, and introduces a dye-free assay.

The paper introduces a modular DNA toolkit for creating long, customizable DNA molecules with user-defined sequences for single-molecule biophysics applications.

This study shows DNA supercoiling enhances ParB-DNA condensation, forming partition complexes at lower ParB concentrations than on relaxed DNA.

The paper shows that dense Rap1 arrays block DNA loop extrusion by condensin in yeast, acting as contact insulators and affecting dicentric chromosome resolution.

This study presents a quantitative model showing how DNA topology modulates binding, with experiments using fluorescent intercalators and psoralen to demonstrate topology-dependent effects.