Author
University of California, IrvineORCID 0000-0003-0196-7996Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Pedro Ortega, Elodie Bournique, Junyi Li…·Rémi Buisson
This study identifies APOBEC3B as the enzyme responsible for ssDNA breakage during replication catastrophe induced by ATR inhibition, revealing a mechanism for PARP1 trapping and synthetic lethality with PARP inhibitors.
Lavanya Manjunath, Gisselle Santiago, Pedro Ortega…·Rémi Buisson
The paper identifies PACT as a key inhibitor of PKR during viral infection and shows that PACT and ADAR1 cooperate to prevent aberrant PKR activation by self-dsRNAs.
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani…·Rémi Buisson
This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.