Author

Brianna Hnath

Pennsylvania State UniversityORCID 0000-0003-0342-4522Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Nikolay V. DokholyaniD· 3 shared Congzhou Mike ShaiD· 1 shared Esther Sue ChoiiD· 1 shared Srinivasan EkambaramiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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3 shared papersMolecular Biology

Nikolay V. DokholyanORCID

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3 papers

Recent·Most cited

Molecular BiologyNeurobiology of DiseasePeer-reviewedFeb 5, 2026

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers

Brianna Hnath, Srinivasan Ekambaram, Nikolay V. Dokholyan

The paper investigates how toxic SOD1 oligomers affect extracellular vesicle release pathways in ALS, identifying key proteins and pathways involved.

3 citationstop 2%

humanexperimental assay

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NeuroscienceStructurePeer-reviewedAug 28, 2024

Unveiling the double-edged sword: SOD1 trimers possess tissue-selective toxicity and bind septin-7 in motor neuron-like cells

Esther Sue Choi, Brianna Hnath, Congzhou Mike Sha, Nikolay V. Dokholyan

This paper identifies tissue-selective toxicity of SOD1 trimers and their interaction with septin-7 in motor neuron-like cells, revealing pathways linked to ALS pathophysiology.

1 citation

humanproteomics

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Molecular BiologyBiophysical JournalPeer-reviewedMay 3, 2022

Toxic SOD1 trimers are off-pathway in the formation of amyloid-like fibrils in ALS

Brianna Hnath, Nikolay V. Dokholyan

This study shows that toxic SOD1 trimers are an off-pathway intermediate competing with protective fibril formation in ALS, and stabilizing trimers reduces larger aggregate formation.

18 citations

experimental assay

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