BiochemistryNature Chemical BiologyPeer-reviewed
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5
Laura A. Hehl, Daniel Horn‐Ghetko, Jesuraj Rajan Prabu…·Brenda Arlene Schulman
This study uses cryo-EM to reveal the structural mechanism of K48-linked ubiquitin chain formation by the HECT E3 ligase UBR5, showing how it orchestrates ubiquitin transfer through conformational changes.