ImmunologybioRxiv
Dabrafenib alters MDSC differentiation and function by activation of GCN2
M. Teresa Ciudad, Rene Quevedo, Sara Lamorte…·Tracy L. McGaha
This study shows that dabrafenib inhibits PMN-MDSC differentiation via GCN2 activation, altering their function and reducing their suppressive activity in tumors.
DOI 10.1158/2767-9764.crc-23-0376