Tracy L. McGaha

This study shows that sex hormones and sex chromosomes have opposing effects on Th17 cell-mediated autoimmunity in mice, with hormones reducing disease severity and chromosomes increasing it.

This study shows that sequential infections in mice remodel immune landscapes, making them more similar to human immunity and affecting future immune responses.

This study identifies a spatially encoded interferon circuit that restricts progenitor exhausted CD8 T cells during chronic infection by enforcing niche sequestration and checkpoint control.

This study shows STING agonists enhance anti-tumor immunity by recruiting monocytic cells and inducing IFN-I responses, with IL-18 playing a key role in CD8 T cell activation.

This study identifies EHMT2 as a key regulator of CAF hyperproliferation and pro-invasive behavior, showing its inhibition reprograms CAFs to a less aggressive state.

This study shows that dabrafenib inhibits PMN-MDSC differentiation via GCN2 activation, altering their function and reducing their suppressive activity in tumors.

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.