Author

Alexandra M. D’Ordine

Brown UniversityORCID 0000-0003-0553-2615Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

G. JogliD· 2 shared George P. LisiiD· 2 shared Giulia PalermoiD· 2 shared Alexa L KnightiD· 1 shared Chinmai PindiiD· 1 shared Erin SkeensiD· 1 shared Helen B BelatoiD· 1 shared Jinping LuoiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

G. JoglORCID

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2 papers

Recent·Most cited

BiophysicseLifePeer-reviewedJul 16, 2024

Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9

Helen B Belato, Alexa L Knight, Alexandra M. D’Ordine…·George P. Lisi

This study investigates how single-atom mutations in the recognition lobe of GeoCas9 affect its structure, dynamics, and guide RNA interactions without altering its functional specificity.

5 citations

bacteria (other)protein structure

𝕏 PostBluesky

BiophysicsScience AdvancesPeer-reviewedMar 6, 2024

High-Fidelity, Hyper-Accurate, and Evolved Mutants Rewire Atomic Level Communication in CRISPR-Cas9

Erin Skeens, Souvik Sinha, Mohd Ahsan…·George P. Lisi

The paper investigates how specific mutations in the Rec3 domain of CRISPR-Cas9 variants affect structural dynamics and allosteric communication to enhance specificity.

53 citationstop 2%

structural biologymechanistic / dynamical model

𝕏 PostBluesky