Xiangxi Wang

The paper compares RSV and hMPV entry strategies, showing RSV uses structural organization for thermotolerance while hMPV uses genomic redundancy for stability.

This study identifies a hierarchical activation threshold in RSV F antibody repertoires, explaining pediatric vulnerability and adult protection through distinct antibody subclasses and epitope targeting.

This paper develops a structure-guided RSV vaccine platform with stabilized prefusion F immunogens and mucosal delivery, showing protection in animal models and advancing to clinical trials.

MAAD provides a curated database of antiviral antibodies with multidimensional features to support rational antibody design and comparative antiviral research.

The paper identifies hedgehog APN as a receptor for EriCoVs and shows convergent evolution in its utilization among merbecoviruses.

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

This study investigates the structural and molecular basis of enhanced ACE2 binding in SARS-CoV-2 KP.3 variant through Cryo-EM and MD simulations, revealing synergistic mutational effects.

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

The paper investigates structural plasticity in Parechovirus 2A proteins, revealing structural rearrangements that affect their oligomeric state and potential function in viral RNA replication.

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.