Author

Yaroslav A. Kainov

King's College LondonORCID 0000-0003-0664-9102Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Cristina DiasiD· 2 shared Tim HubbardiD· 2 shared Andres RamosiD· 1 shared Eugene V. MakeyeviD· 1 shared Fursham HamidiD· 1 shared Ingrid M. WentzenseniD· 1 shared Mary-Alice Abbott· 1 shared Patricia A. Foley· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Cristina DiasORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintNov 10, 2026

Inactivating mutations in polyadenylation factor CSTF2 disrupt intronic polyadenylation patterns and are associated with intellectual disability.

Yaroslav Kainov, Patricia A. Foley, Rebecca Igbokwe…·Cristina Dias

This study identifies inactivating CSTF2 variants in males with intellectual disability and shows they disrupt intronic polyadenylation patterns, linking CSTF2 to neurodevelopmental disorders.

DOI 10.64898/2026.11.10.26367664

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintFeb 16, 2025

Genome-Wide Analysis Reveals a Role of 3'untranslated Region Variants Affecting Cleavage and Polyadenylation in Undiagnosed Rare Disorders

Yaroslav A. Kainov, Cristina Dias, Tim Hubbard

The paper identifies 3'UTR variants disrupting cleavage and polyadenylation as potential causes of undiagnosed rare disorders using deep learning on Genomics England data.

1 citation

humanwhole-genome sequencing

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Cancer BiologyeLifePeer-reviewedAug 22, 2024

Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

Yaroslav A. Kainov, Fursham Hamid, Eugene V. Makeyev

This study identifies somatic mutations in cleavage and polyadenylation signals of tumour suppressor genes as a novel class of noncoding drivers in cancer.

6 citations

humanwhole-genome sequencing

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