Author

Steven McFarlane

MRC University of Glasgow Centre for Virus ResearchORCID 0000-0003-0710-1499Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Chris BoutelliD· 3 shared Anna Ruth CliffeiD· 2 shared Ilaria EpifanoiD· 2 shared Lauren Orr· 2 shared Abigail WhitfordiD· 1 shared Ali Rohani· 1 shared Alison K. FrancoisiD· 1 shared Ana da Silva FilipeiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Chris BoutellORCID

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3 papers

Recent·Most cited

MicrobiologyPLoS PathogensPeer-reviewedAug 20, 2025

Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription

Ashley P. E. Roberts, Anne Orr, Victor Iliev…·Chris Boutell

This study identifies Daxx-mediated histone H3.3 deposition on HSV-1 DNA as a host restriction factor that limits genome decompaction and immediate-early transcription.

9 citationstop 4%

humanimaging

𝕏 PostBluesky

MicrobiologymBioPeer-reviewedFeb 27, 2024

Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts

Alison K. Francois, Ali Rohani, M. S. Loftus…·Anna Ruth Cliffe

This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.

16 citationstop 4%

humanChIP-seq

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MicrobiologybioRxivPreprintSep 29, 2023

Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV

Christopher Davis, Ilaria Epifano, Kieran Dee…·Chris Boutell

This study shows that fever enhances the host's type-I IFN response to restrict MPXV replication.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky