Chris Boutell

This study uses cryo-CLEM to reveal the molecular structure of PML bodies, identifying columnar trinucleosome assemblies and a porous interior that may facilitate chromatin partitioning.

This study shows that H2AK119ub1, deposited by PRC1, is critical for HSV-1 reactivation from latency, while H3K27me3 is not.

This study identifies Daxx-mediated histone H3.3 deposition on HSV-1 DNA as a host restriction factor that limits genome decompaction and immediate-early transcription.

This study shows that interferon-induced H3K9me3 and ATRX restrict HSV-1 reactivation by maintaining epigenetic memory during neuronal latency.

This study uses machine learning to identify key viral and host processes associated with varying severity in bluetongue virus infection in sheep.

This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.