Srinivasan Yegnasubramanian

The paper identifies a WIF1+ basal cell subtype enriched in the transition zone of the prostate and links it to benign prostatic hyperplasia through molecular and pathway analyses.

The paper identifies 17 consensus transcriptomic programs in ccRCC using NMF and links them to cellular sources and clinical outcomes, revealing converging trajectories toward aggressive disease.

This paper identifies triptolide as a compound that enhances the effectiveness of DNMTi by inhibiting DCTPP1, overcoming resistance in cancer cells.

This study shows that loss of miR-21 in MYC-driven prostate cancer reduces tumor progression by affecting cell-type-specific gene regulation and immune infiltration.

SVCFit estimates SV cellular fractions from bulk sequencing to reconstruct clonal evolution in mCRPC under therapy, showing treatment-driven clonal reconfiguration.

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

This paper introduces sgGOLDFISH, a method for single-nucleotide sensitivity in direct hybridization genome imaging, and demonstrates its application in identifying and localizing point mutations in progeroid fibroblasts.