Author

Florian Wegwitz

Universitätsmedizin GöttingenORCID 0000-0003-0750-6998Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andreas TrumppiD· 1 shared Anna Blandau· 1 shared Argyris PapantonisiD· 1 shared Barbara T. GrünwaldiD· 1 shared Bettina Mundt· 1 shared Bjoern PapkeiD· 1 shared Daniel T. GrimmiD· 1 shared Elisa EspinetiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Andreas TrumppORCID

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2 papers

Recent·Most cited

Cancer BiologyCell Death and DifferentiationPeer-reviewedApr 9, 2025

Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition

Tamara Isermann, Kim Lucia Schneider, Florian Wegwitz…·Ramona Schulz‐Heddergott

This study shows that combining HSP90 inhibitors with p53 activation or CDK4/6 inhibition enhances colorectal cancer therapy by disrupting the HSF1-HSR feedback loop.

19 citationstop 4%

mousehuman

𝕏 PostBluesky

Cancer BiologyNature CommunicationsPeer-reviewedJan 6, 2025

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

Lukas Klein, Mengyu Tu, Niklas Krebs…·Shiv K. Singh

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

54 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky