Author

Sarah Spiegel

Virginia Commonwealth UniversityORCID 0000-0003-0751-2634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ryan D. R. BrowniD· 2 shared Andrea GraziadeiiD· 1 shared Anna KovilakathiD· 1 shared Daniel M. GreifiD· 1 shared Denisa JamecnaiD· 1 shared Doris HöglingeriD· 1 shared Eunate Gallardo‐VaraiD· 1 shared Fabio LolicatoiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Ryan D. R. BrownORCID

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3 papers

Recent·Most cited

Developmental BiologyNature Cardiovascular ResearchPeer-reviewedJan 5, 2026

Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization

Junichi Saito, Jui M. Dave, Eunate Gallardo‐Vara…·Daniel M. Greif

This study identifies SPHK1 as a key driver of SMC hyperproliferation in elastin deficiency, showing its role in both pathological and physiological arterial remodeling.

2 citations

mousehuman

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BiochemistrybioRxivPreprintOct 16, 2025

Depot-specific roles for sphingosine kinase 1 in conversion of white adipose to thermogenic adipose

Yolander A. Valentine, Maryam Jamil, Anna Kovilakath…·L. Ashley Cowart

This study investigates the role of SphK1 in adipose thermogenesis and mitochondrial function, finding depot-specific effects on beiging and metabolic outcomes.

DOI 10.1101/2025.10.16.682897

mousebulk RNA-seq

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Cell BiologybioRxivPreprintSep 18, 2023

The sterol transporter STARD3 transports sphingosine at ER-lysosome contact sites

Pia Hempelmann, Fabio Lolicato, Andrea Graziadei…·Denisa Jamecna

The paper identifies STARD3 as a sphingosine transporter at ER-lysosome contact sites, showing its role in sphingosine integration into ceramide.

13 citations

humanproteomics

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