Cancer BiologyCell Death and DiseasePeer-reviewed
Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia
Gioia Boncompagni, Vanessa Tatangelo, Ludovica Lopresti…·Cosima T. Baldari
This study shows that IL-9 secreted by leukemic cells suppresses CTL-mediated killing in CLL by increasing PD-1 expression and impairing immune synapse formation.