Abdullah Obaid Khan

A first-in-class CAR T-cell therapy targeting mutant calreticulin selectively depletes malignant stem cells in vivo and in fibrotic human organoids.

This paper introduces comBOs, a new human bone and lympho-myeloid bone marrow organoid model that includes multiple cell types and improves upon existing models for studying haematopoietic disorders.

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

This paper presents an analysis workflow for quantifying platelet spreading and morphology using image segmentation and machine learning, with tools available in KNIME and ilastik.

The paper introduces a topological data analysis method for analyzing single molecule localization microscopy data, improving segmentation and quantifying nano-structure.

This study optimizes CRISPR-Cas9 for single molecule imaging by improving mEos variants and shows endogenous labeling enables accurate quantification of CXCR4.